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Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Though temsirolimus shows activity on its own, it is also known to be converted to sirolimus (rapamycin) in vivo; [4] therefore, its activity may be more attributed to its metabolite rather than the prodrug itself (despite claims to the ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
Consumer Reports (CR), formerly Consumers Union (CU), is an American nonprofit consumer organization dedicated to independent product testing, investigative journalism, consumer-oriented research, public education, and consumer advocacy.
Doctors explain the safest and most effective way to blow your nose. Here, experts share how to remove mucus quickly and safely.
When it comes to managing mild pain at home, there’s a strong probability you’ve already got a few types of OTC anti-inflammatories stocked in your medicine cabinet.
At least two people have died as severe storms and tornadoes tore through parts of Texas and Mississippi on Saturday, officials said, while a parade of atmospheric river-fueled storms batters the ...
ConsumerAffairs is an American customer review and consumer news platform that provides information for purchasing decisions around major life changes or milestones. [5] The company's business-facing division provides SaaS that allows brands to manage and analyze review data to improve their products and customer service.
Some dog breeds look completely different as puppies. From the Bergamasco to the Tibetian Terrier, these pups have appearances that change as they grow up
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