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Following a single oral dose of 2.5 mg tibolone, peak serum levels of tibolone were 1.6 ng/mL, of δ 4-tibolone were 0.8 ng/mL, of 3α-hydroxytibolone were 16.7 ng/mL, and of 3β-hydroxytibolone were 3.7 ng/mL after 1 to 2 hours. [1] The elimination half-life of tibolone is 45 hours. [8] It is excreted in urine 40% and feces 60%. [5] [8]
Omarigliptin (MK-3102) is a potent, long-acting oral antidiabetic drug of the DPP-4 inhibitor class used for once-weekly treatment of type 2 diabetes and currently under development by Merck & Co. [1] It inhibits DPP-4 to increase incretin levels (GLP-1 and GIP), [2] [3] [4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying and decreases ...
Administration of levamlodipine (2.5 mg) as a single dose gives maximum plasma concentration (C max) of 8.3 to 9.3 ng/mL in 2 to 3 hrs (T max).It is extensively (about 90%) converted to inactive metabolites via hepatic metabolism with 10% of the parent compound and 60% of the metabolites excreted in the urine.
The basic concept of MagSafe is derived from the magnetic power connectors that are part of many deep fryers and Japanese countertop cooking appliances since the early 2000s in order to avoid spilling their dangerously hot contents. [2] [3] [4] [failed verification] MagSafe was introduced on January 10, 2006 in the first-generation MacBook Pro. [5]
Most Lightning devices only support USB 2.0, which has a maximum transfer speed of 480 Mbit/s or 60 MB/s. With USB 2.0, only one lane is in use at a time. [24] [25] Only the 12.9-inch iPad Pro (1st and 2nd generation) and 10.5-inch iPad Pro support USB 3.0 (now USB 3.2 Gen 1), which has a maximum transfer speed of 5 Gbit/s or 625 MB/s. [9]
For every 3 non-theme words you find, you earn a hint. Hints show the letters of a theme word. If there is already an active hint on the board, a hint will show that word’s letter order.
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