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After one week on the 4 mg dose, my only side effect was an occasional pain in my right lower abdominal area which is a normal side effect. It was only after the second week of taking sirolimus ...
Attia also created the blog "The Eating Academy" (later "War on Insulin" and now peterattiamd.com) that mostly focuses on topics related to nutrition, physical activity, and longevity. Subsequently, he launched the podcast "The Peter Attia Drive", in which he interviews various experts each week, covering topics such as longevity, metabolic ...
Affecting an estimated one-third of the population, insomnia can lead to significant short- and long-term health effects. Insomnia isn't just about fatigue; it can increase the risk of chronic ...
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
A drug of last resort (DoLR), also known as a heroic dose, [1] is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance , such as antimicrobial resistance or antineoplastic resistance , may make the first-line drug ineffective, especially in case of ...
Laboratory data from an unpublished analysis of the same cohort also support the lack of dose-dependency of metabolic side effects, as new use of low-dose quetiapine was associated with a risk of increased fasting triglycerides at one-year follow-up. [192] Concerns regarding side effects are greater in the elderly. [193]
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonist or DORA) of the orexin receptors, OX 1 and OX 2. [1]