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The metastatic tumor cells grow either attached to the pia mater covering the brain and spinal cord or floating unattached to the subarachnoid space. [7] Tumors of diverse origins and hematologic cancers may spread to this space. [5] Some patients can develop a leptomeningeal tumor while receiving chemotherapy for their primary tumor. [citation ...
Company to present ReSPECT-LM Phase 1 trial data on Rhenium (186 Re) Obisbemeda with a focus on treating leptomeningeal metastases (LM) in breast cancer patientsAUSTIN, Texas, Dec. 04, 2024 (GLOBE NEWSWIRE) -- Plus Therapeutics, Inc. (Nasdaq: PSTV) (“Plus” or the “Company”), a clinical-stage pharmaceutical company developing targeted radiotherapeutics with advanced platform ...
Plus Therapeutics is developing nanoliposome-encapsulated BMEDA-chelated radioisotope drugs to treat various types of cancer. Rhenium (186Re) Obisbemeda is a Rhenium-186 radiolabeled therapeutic targeting recurrent glioblastoma, leptomeningeal metastases, and pediatric brain cancers.
These processes tend to cause seizures early in the course because of their cortical location. Metastasis to the leptomeninges is an uncommon but well-recognized clinical presentation in cancer patients. Leptomeningeal metastasis most commonly is due to breast, lung, or melanoma primary tumors. [2]
3.3 Leptomeningeal carcinomatosis. 4 Treatment. 5 ... A pattern of multiple small nodular metastases has been described as miliary carcinosis which has a radiographic ...
Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare, primary CNS tumor, classified as distinct entity in 2016 [1] and described as diffuse oligodendroglial-like leptomeningeal tumor of children in the 2016 classification of CNS neoplasms by the WHO., [2] Typically, it's considered juvenile tumors [3] but can occur in adults, [4] the average age of diagnosis is five years. [3]
Treatment and prognosis depend on factors such as the type of tumor, location, and molecular characteristics. [1] Although primary nervous system neoplasms are relatively rare, secondary (metastatic) tumors are more common in adults. [2]
No one from Vitas had called to warn the family that the woman everyone called “granny” was in sharp decline, Spry said. No one from Vitas had sought treatment for the blood infection that had made her severely ill, despite the family’s standing request that she receive life-saving care in the event of a crisis.