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The risk of enlarged ventricles on brain scan (associated with schizophrenia symptoms and biologically suggestive of Emil Kraepelin's dementia praecox) was greatly increased if the subjects had both a higher genetic load for schizophrenia and lower birthweight. The investigators suggested that in utero insults may specifically stress those with ...
Schizophrenia affects around 0.3–0.7% of people at some point in their life. [19] [14] In areas of conflict this figure can rise to between 4.0 and 6.5%. [254] It occurs 1.4 times more frequently in males than females and typically appears earlier in men. [87] Worldwide, schizophrenia is the most common psychotic disorder. [56]
There is also clinical evidence of the value of SSRIs in the treatment of the symptoms of schizophrenia and their ability to prevent cardiovascular diseases. [1] SSRIs primarily inhibit serotonin transporter (SERT) in the brain and have negligible effects on dopamine transporter (DAT) and norepinephrine transporter (NET).
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Selective serotonin reuptake inhibitors work by boosting your serotonin levels. Serotonin, a brain messenger that you might know as the "happy hormone" (along with dopamine and others), helps ...
The PANSS is a 30-item scale that measures symptoms of schizophrenia. [2] Each item is rated by a clinician on a seven-point scale. [2] In both studies, the participants who received xanomeline/trospium chloride experienced a meaningful reduction in symptoms from baseline to week 5 as measured by the PANSS total score compared to the placebo ...
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