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A phase III study of sunitinib treatment in well differentiated pNET that had worsened within the past 12 months (either advanced or metastatic disease) showed that sunitinib treatment improved progression-free survival (11.4 months vs. 5.5 months), overall survival, and the objective response rate (9.3% vs. 0.0%) when compared with placebo. [30]
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The peripheral PNET (pPNET) is now thought to be virtually identical to Ewing sarcoma: "Current evidence indicates that both Ewing's sarcoma and PNET have a similar neural phenotype and, because they share an identical chromosome translocation, they should be viewed as the same tumor, differing only in their degree of neural differentiation.
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However, a positive correlation between individuals with Li-Fraumeni syndrome with a mutation in the gene p53 and PNET has been reported. [2] A significant number of individuals with mutations on the rb tumor suppressor gene have also developed the tumor. [2] Such gene encodes for the protein Rb responsible for stopping the cell cycle at the G1 ...
PNET may refer to: Peaceful Nuclear Explosions Treaty; Primitive neuroectodermal tumor; Pancreatic neuroendocrine tumor This page was last edited on 20 ...
The Eastern Front was a theatre of World War II which primarily involved combat between the nations and allies of Nazi Germany and the Soviet Union.Combat in the Eastern Front began with the two powers remaining peaceful towards each other, with the annexation of countries such as Albania and portions of Poland by Germany and its allies, and the annexation of Finland and the rest of Poland by ...