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The renal clearance ratio or fractional excretion is a relative measure of the speed at which a constituent of urine passes through the kidneys. [ 1 ] [ 2 ] It is defined by following equation: c l e a r a n c e r a t i o o f X = C x C i n {\displaystyle clearance\ ratio\ of\ X={\frac {C_{x}}{C_{in}}}}
Can be applied to patients with residual renal function; it is possible to demonstrate that C o is a function of the residual kidney function and the "cleaning" provided by dialysis. The model can be applied to substances other than urea, if the clearance, K , and generation rate of the substance, m ˙ {\displaystyle {\dot {m}}} , are known.
where C is the concentration [mol/m 3]; t is the time [s]; K is the clearance [m 3 /s]; V is the volume of distribution [m 3]; From the above definitions it follows that is the first derivative of concentration with respect to time, i.e. the change in concentration with time.
Creatinine clearance exceeds GFR due to creatinine secretion, [4] which can be blocked by cimetidine. Both GFR and C Cr may be accurately calculated by comparative measurements of substances in the blood and urine, or estimated by formulas using just a blood test result ( eGFR and eC Cr ) The results of these tests are used to assess the ...
Therefore, creatinine concentrations in blood and urine may be used to calculate the creatinine clearance (CrCl), which correlates approximately with the glomerular filtration rate (GFR). Blood creatinine concentrations may also be used alone to calculate the estimated GFR (eGFR). The GFR is clinically important as a measurement of kidney function.
The glomerular filtration rate is the flow rate of filtered fluid through the kidney. The creatinine clearance rate (C Cr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR. Creatinine clearance exceeds GFR due to creatinine secretion, [1] which can be blocked by ...
Volume of blood plasma delivered to the kidney per unit time. PAH clearance is a renal analysis method used to provide an estimate. Approximately 625 ml/min. renal blood flow = (HCT is hematocrit) Volume of blood delivered to the kidney per unit time. In humans, the kidneys together receive roughly 20% of cardiac output, amounting to 1 L/min in ...
A physiologic interpretation of clearance (at steady-state) is that clearance is a ratio of the mass generation and blood (or plasma) concentration. Its definition follows from the differential equation that describes exponential decay and is used to model kidney function and hemodialysis machine function: