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Established in 1998, UMSC was initially located at University Malaya Medical Centre (UMMC) and in 2007 shifted to UMSC's own building. It is adjacent to the largest teaching hospital in Malaysia, UMMC and Malaysia's oldest medical school, the Faculty of Medicine, University of Malaya founded in 1962 which shares its roots with the National University of Singapore's Yong Loo Lin School of Medicine.