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7-Hydroxymitragynine (7-OH) is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as kratom. [2] It was first described in 1994 [3] and is a human metabolite metabolized from mitragynine present in the Mitragyna speciosa. 7-OH binds to opioid receptors like mitragynine, but research suggests that 7-OH binds with greater efficacy.
[32] [11] [9] The alkaloids mitragynine and 7-hydroxymitragynine are responsible for many of the complex effects of kratom, [11] [9] but other alkaloids may also contribute synergistically. [32] The effects of both mitragynine and 7-HMG remain disputed despite substantial study. Both are partial agonists of the μ-opioid receptor.
Mitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. [4] It is an opioid that is typically consumed as a part of kratom for its pain-relieving and euphoric effects.
Dr. Carrie Jose, in her latest Health and Wellness column, ... Dr. Carrie Jose, in her latest Health and Wellness column, describes what are the hidden risks of relying on back MRIs
A new medication developed in the 1970s, buprenorphine, was viewed as a safer alternative to methadone because it had a lower overdose risk. “Bupe,” as it’s become known, was originally approved for pain relief, but knowledgeable addicts began using it as a black market route to drug rehabilitation.
Given the overlap between synthetic biology and the do-it-yourself biology movement, concerns have been raised that its practitioners may not abide by risk assessment and biosafety practices required of professionals, [2]: 39 although it has been suggested that an informal code of ethics exists that recognizes health risks and other adverse ...
Studies back that up — and show exactly why this happens. Our brains are, quite literally, not designed to do two things simultaneously. When we attempt to do so anyway, it requires more neural ...
Ergonomics refers to how safe and efficient you are in your working environment. Bad ergonomics will typically cost you unnecessary energy and labor - and can often result in an injury.