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Doxycycline is a broad-spectrum antibiotic of the tetracycline class used in the treatment of infections caused by bacteria and certain parasites. [1] It is used to treat bacterial pneumonia , acne , chlamydia infections , Lyme disease , cholera , typhus , and syphilis . [ 1 ]
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
The antibiotics most frequently used to treat acne vulgaris are erythromycin, clindamycin, doxycycline, and minocycline. [40] [41] [42] Several other families of antibiotics are also active against C. acnes bacteria, including quinolones, cephalosporins, pleuromutilins, penicillins, and sulfonamides. [43] [44] [45]
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The use of doxycycline in acne vulgaris has been associated with increased risk of Crohn's disease, [9] although a later study indicated a link between acne vulgaris and IBS irrespective of the use of antibiotics. [10] Likewise, the use of minocycline in acne vulgaris has been associated with skin and gut dysbiosis. [11]
The drug isn’t generally used as a so-called first-line treatment for acne. It’s considered an option for women if other medications, including creams or oral antibiotics, don’t work.
“Most acne treatments—like cleansers, spot treatments, and lotions—contain salicylic acid in the 0.5 to two percent range,” she says. “One to two percent is common for spot treatments ...
Treatment of Clostridioides (formerly Clostridium) difficile infection. [8] May be more narrow-spectrum than vancomycin, resulting in less bowel microbiota alteration. [9] Nausea (11%), vomiting, and abdominal pain. [10] Bactericidal in susceptible organisms such as C. difficile by inhibiting RNA polymerase, thereby inhibiting protein synthesis ...