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Aclidinium bromide/formoterol, sold under the brand names Duaklir and Brimica, is a fixed-dose combination medication for inhalation, used in the management of chronic obstructive pulmonary disease (COPD). [5] It consists of aclidinium bromide, a long-acting muscarinic antagonist, and formoterol, a long-acting β 2 agonist. [3] [4]
It is marketed under the brand name Tudorza Pressair in the US, Eklira Genuair in the UK, and Tudorza Genuair in Canada; licensed to Menarini under the brand name Bretaris Genuair for majority of EU member states. [10] An inhalable combination with formoterol is marketed as Brimica Genuair [11] and Duaklir Genuair [12] in the European Union.
Formoterol, also known as eformoterol, is a long-acting β 2 agonist (LABA) used as a bronchodilator in the management of asthma and chronic obstructive pulmonary disease (COPD). Formoterol has an extended duration of action (up to 12 h) compared to short-acting β 2 agonists such as salbutamol (albuterol), which are effective for 4 h to 6 h.
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With the exception of formoterol, LABAs are not recommended for the treatment of acute asthma exacerbations because of their slower onset of action compared to salbutamol. Their long duration of action is due to the addition of a long lipophilic side-chain that binds to an exosite on adrenergic receptors.
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Arformoterol, sold under the brand name Brovana among others, is a medication used for the treatment of chronic obstructive pulmonary disease (COPD). [1] [2] It is a long-acting β 2 adrenoreceptor agonist (LABA) and it is the active (R,R)-(−)-enantiomer of formoterol. [1] It was approved for medical use in the United States in October 2006. [1]
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