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Compared with other existing imaging technologies, laser speckle contrast imaging has several obvious advantages. It can uses simple and cost-effective instrument to return excellent spatial and temporal resolution imaging. And due to these strengths, laser speckle contrast imaging has been involved in mapping blood flow for decades.
Laser Doppler imaging (LDI) is an imaging method that uses a laser beam to image live tissue. When the laser light reaches the tissue, the moving blood cells generate Doppler components in the reflected (backscattered) light. The light that comes back is detected using a photodiode that converts it into an electrical signal.
The photoacoustic Doppler effect is a type of Doppler effect that occurs when an intensity modulated light wave induces a photoacoustic wave on moving particles with a specific frequency. The observed frequency shift is a good indicator of the velocity of the illuminated moving particles. A potential biomedical application is measuring blood flow.
Therefore, there is an urgent need for a way to measure blood flow. However, blood flow is difficult to measure because of sensitivity and stability of the measurement as it depends on magnitude of flow, location, and the diameter of individual vessels. [2] Current imaging modalities used to measure blood flow include Doppler ultrasound, PET ...
Laser Doppler imaging by digital holography can measure blood flow in the retina and choroid, whose Doppler responses exhibit a pulse-shaped profile with time [38] [39] This technique enables non invasive functional microangiography by high-contrast measurement of Doppler responses from endoluminal blood flow profiles in vessels in the ...
SV-OCT uses the inter-frame variance of image intensities to compute blood flow. Areas that have high flow will have higher motion of scattering particles and this information is encoded in the speckle pattern. [citation needed] SV-OCT has advantages for microvasculature imaging due to its high sensitivity and independence to the Doppler angle.
laser Doppler imaging of pulse waves on the surface of the hand by holographic photoplethysmography from on-axis digital interferometry. Principal component analysis of digital holograms [23] reconstructed from digitized interferograms acquired at rates beyond ~1000 frames per second reveals surface waves on the hand. This method is an ...
In the fields of cardiology and medical imaging, speckle tracking echocardiography (STE) is an echocardiographic imaging technique. It analyzes the motion of tissues in the heart by using the naturally occurring speckle pattern in the myocardium (or motion of blood when imaged by ultrasound ).