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A study of high-dose bicalutamide monotherapy (300–600 mg/day) in 248 men with LAPC or metastatic prostate cancer found that there were no effects of bicalutamide on heart rate, blood pressure, or electrocardiogram parameters.
The compensatory constriction of the arteries and increased heart rate can cause blood pressure to overshoot normal values, triggering the opposite baroreflex. This time, the brain increases parasympathetic signalling and decreases sympathetic signalling, causing a decrease in heart rate (the turbulence slope part of HRT).
The effect of HRT in menopause appears to be divergent, with lower risk of heart disease when started within five years, but no impact after ten. [ 40 ] [ 41 ] [ 42 ] For women who are in early menopause and have no issues with their cardiovascular health, HRT comes with a low risk of adverse cardiovascular events. [ 43 ]
Less common (but serious) side effects of all post-menopausal estrogens include increased risk or severity of breast, ovarian or uterine cancer; stroke; heart attack; blood clots; dementia; gallbladder disease; high blood pressure, liver problems; high blood sugar, fluid retention, enlargement of benign tumors of the uterus; a spotty darkening ...
Hormone replacement therapy (HRT), also known as menopausal hormone therapy (MHT), is for women with menopausal symptoms. It is based on the idea that the treatment may prevent discomfort caused by diminished circulating estrogen and progesterone hormones, or in the case of the surgically or prematurely menopausal, that it may prolong life and may reduce incidence of dementia. [1]
A medical monitoring device displaying a normal human heart rate. Heart rate is the frequency of the heartbeat measured by the number of contractions of the heart per minute (beats per minute, or bpm). The heart rate varies according to the body's physical needs, including the need to absorb oxygen and excrete carbon dioxide.
The drop in estrogen with menopause can worsen existing cardiovascular conditions like atherosclerosis, high cholesterol and high blood pressure, increasing the risk of heart attacks and strokes ...
The resting heart rate of a newborn can be 120 beats per minute (bpm) and this gradually decreases until maturity and then gradually increases again with age. The adult resting heart rate ranges from 60 to 100 bpm. Exercise and fitness levels, age and basal metabolic rate can all affect the heart rate. An athlete's heart rate can be lower than ...