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Arterial stiffness may also affect the time at which pulse wave reflections return to the heart. As the pulse wave travels through the circulation it undergoes reflection at sites where the transmission properties of the arterial tree change (i.e. sites of impedance mismatch). These reflected waves propagate backward towards the heart.
The theory of the velocity of the transmission of the pulse through the circulation dates back to 1808 with the work of Thomas Young. [9] The relationship between pulse wave velocity (PWV) and arterial wall stiffness can be derived from Newton's second law of motion (=) applied to a small fluid element, where the force on the element equals the product of density (the mass per unit volume ...
Compliance diminishes with age and menopause. Arterial compliance is measured by ultrasound as a pressure (carotid artery) and volume (outflow into aorta) relationship. [5] Compliance, in simple terms, is the degree to which a container experiences pressure or force without disruption. It is used as an indication of arterial stiffness.
A simple view of the hemodynamics of systemic arterial pressure is based around mean arterial pressure (MAP) and pulse pressure. Most influences on blood pressure can be understood in terms of their effect on cardiac output, [77] systemic vascular resistance, or arterial stiffness (the inverse of arterial compliance). Cardiac output is the ...
The arterial compliance - the amount of tension produced per stretch of arteries, decreases with age, and the stiffness of arteries increases with age. [3] The structural change in blood vessels causes the elderly to be more susceptible to hypertension, which leads to complications in arteries, the heart and even the brain.
Atherosclerosis [a] is a pattern of the disease arteriosclerosis, [8] characterized by development of abnormalities called lesions in walls of arteries.This is a chronic inflammatory disease involving many different cell types and driven by elevated levels of cholesterol in the blood. [9]
Pulse wave velocity is used to monitor arterial stiffness; which increases with age and high blood pressure, leading to a higher probability of cardiovascular problems including hypertension or a stroke. [49]
This is probably due to vascular calcification causing increased arterial stiffness, increased pulse pressure and resulting in exaggerated damage to the heart and kidneys. [12] The clinical symptoms of Mönckeberg's arteriosclerosis are similar to giant cell arteritis in which the two can be mistakenly interchanged.