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Losing weight is hard, but it’s especially challenging for women with polycystic ovarian syndrome (PCOS)—a health condition that affects 1 in 10 women between the ages of 15 and 44. Women with ...
Weight loss can be tricky, period. But those with PCOS may find themselves struggling to drop pounds even more than the average person.. Polycystic ovary syndrome, or PCOS, is a hormone disorder ...
“When interventions focus on the root cause of weight gain — insulin resistance — PCOS symptoms are more likely to improve. Directly addressing insulin resistance is essential for achieving ...
Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age. [14] The syndrome is named after cysts which form on the ovaries of some women with this condition, though this is not a universal symptom, and not the underlying cause of the disorder.
Why Does PCOS Cause Weight Gain? The body is a complex system and several interconnected mechanisms can make it harder to lose weight when you have PCOS. First, insulin resistance is common in PCOS.
Gynecomastia induced by spironolactone usually regresses after a few weeks following discontinuation of the medication. [110] However, after a sufficient duration of gynecomastia being present (e.g., one year), hyalinization and fibrosis of the tissue occurs and drug-induced gynecomastia may become irreversible. [136] [137]
Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6]
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