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Saw palmetto has been shown to reduce the levels of PSA in the blood, a hormone produced by the prostate and used as a marker by healthcare providers to evaluate the presence of prostate cancer. Taking saw palmetto can artificially reduce the levels of PSA, interfering with test results. [8]
In animal studies, GTx-758 reversibly suppresses testosterone concentrations to castrate levels, reduces prostate size and levels of prostate-specific antigen (PSA), but does not induce typical side effects associated with hyperestrogenism (or hypoestrogenism) including hot flashes, bone loss, thrombophilia, hypercoagulation, or increased body fat. [1]
Median PSA reduction (%) with bicalutamide monotherapy at different dosages (mg/day) and with castration monotherapy. [56] Whereas testosterone is the major circulating androgen, DHT is the major androgen in the prostate gland. [57] DHT levels in circulation are relatively low and only approximately 10% of those of circulating testosterone ...
The other is a PSA blood test, which measures the amount of a protein that’s produced by cancerous and noncancerous cells in the prostate. “Elevated PSA levels can be an indicator of prostate ...
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
[9] [10] It can also reduce DHT levels in the prostate by 97 to 99% in men with prostate cancer. [11] [12] Epristeride (brand names Aipuliete, Chuanliu) is marketed in China for the treatment of benign prostatic hyperplasia. [13] [14] [15] However, it can only decrease circulating DHT levels by about 25 to 54%. [16]
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