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Synovial fluid is an ultrafiltrate from blood, and contains proteins derived from the blood plasma and proteins that are produced by cells within the joint tissues. [4] The fluid contains hyaluronan secreted by fibroblast-like cells in the synovial membrane, lubricin (proteoglycan 4; PRG4 ) secreted by the surface chondrocytes of the articular ...
The water of synovial fluid is not secreted as such but is effectively trapped in the joint space by the hyaluronan. The macrophage-like synovial cells (derived from monocytes in blood) [3] are responsible for the removal of undesirable substances from the synovial fluid (hence are rich in Golgi apparatus). It accounts for approximately 25% of ...
The inner layer is mainly composed of two cell types, specialized macrophages (macrophage-like synovial cells) and fibroblast-like synoviocytes, which are important in maintaining the internal joint homeostasis. These cells represent the main source of hyaluronic acid and also other glycoproteins, major components of the synovial fluid. [1] [2]
The transcellular fluid is the portion of total body fluid that is formed by the secretory activity of epithelial cells and is contained within specialized epithelial-lined compartments. Fluid does not normally collect in larger amounts in these spaces, [6] [7] and any significant fluid collection in these spaces is physiologically ...
For example, synovial membranes surround the joints of the shoulder, elbow, and knee. Fibroblasts in the inner layer of the synovial membrane release hyaluronan into the joint cavity. The hyaluronan effectively traps available water to form the synovial fluid , a natural lubricant that enables the bones of a joint to move freely against one ...
The synovial cavity/joint is filled with synovial fluid. The joint capsule is made up of an outer layer of fibrous membrane, which keeps the bones together structurally, and an inner layer, the synovial membrane, which seals in the synovial fluid. They are the most common and most movable type of joint in the body of a mammal.
The primary cells of cartilage are chondrocytes, which are in a matrix of fibrous tissue, proteoglycans and glycosaminoglycans. [2] [3] As cartilage does not have lymph glands or blood vessels, the movements of solutes, including nutrients, occur via diffusion within the fluid compartments contiguous with adjacent tissues. [2]
Cell Count and Differential: In cases of bacterial joint infections, synovial fluid will typically show white blood cell counts of 50,000 to 150,000 cells/mm 3. Cases of inflammatory arthritis are also likely to have an elevated white blood cell count in the synovial fluid, although the count will typically be lower than that seen in septic ...