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To see any decrease or increase in the levels of globulin fraction it should be done in the serum electrophoresis and be checked for any certain abnormalities. [ 5 ] Globulins are usually tested through a blood test to see how much protein is in a patient's blood.
Serum protein electrophoresis (SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins. [1] The most common indications for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma , a monoclonal gammopathy of uncertain significance (MGUS), or further investigate a discrepancy ...
For example, assume that Drug A and Drug B are both protein-bound drugs. If Drug A is given, it will bind to the plasma proteins in the blood. If Drug B is also given, it can displace Drug A from the protein, thereby increasing Drug A's fraction unbound. This may increase the effects of Drug A, since only the unbound fraction may exhibit activity.
This increase has little adverse effect on the health but is used as a diagnostic clue. An increase in α 2-Macroglobulin with normal amount of albumin mainly indicates acute and/or chronic inflammation. [19] A common variant (29.5%) (polymorphism) of α 2-macroglobulin leads to increased risk of Alzheimer's disease. [20] [21]
Serum total protein, also known as total protein, is a clinical chemistry parameter representing the concentration of protein in serum. [1] Serum contains many proteins including serum albumin, a variety of globulins, and many others. While it is possible to analyze these proteins individually, total protein is a relatively quick and ...
Positive acute-phase proteins serve (as part of the innate immune system) different physiological functions within the immune system.Some act to destroy or inhibit growth of microbes, e.g., C-reactive protein, mannose-binding protein, [3] complement factors, ferritin, ceruloplasmin, serum amyloid A and haptoglobin.
Alpha globulins are a group of globular proteins in plasma [1] that are highly mobile in alkaline or electrically charged solutions. They inhibit certain blood proteases and show significant inhibitor activity. The alpha globulins typically have molecular weights of around 93 kDa.
A macroglobulin is a plasma globulin of high molecular weight. [1] Elevated levels of macroglobulins (macroglobulinemia) may cause manifestations of excess blood viscosity (as is the case for IgM antibodies in Waldenström macroglobulinemia) and/or precipitate within blood vessels when temperature drops (as in cryoglobulinaemia).