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The terminal web is a filamentous structure found at the apical surface of epithelial cells that possess microvilli. It is composed primarily of actin filaments stabilized by spectrin, which also anchors the terminal web to the apical cell membrane. The presence of myosin II and tropomyosin helps to explain the contractile ability of the ...
The plus ends of the actin filaments are located at the tip of the microvillus and are capped, possibly by capZ proteins, [2] while the minus ends are anchored in the terminal web composed of a complicated set of proteins including spectrin and myosin II. The space between microvilli at a cell's surface is called the intermicrovillous space.
Other cellular extensions that protrude from the cell membrane are known as membrane protrusions or cell protrusions, also cell appendages, such as flagella, and microvilli. [8] [9] Microtentacles are cell protrusions attached to free-floating cells, associated with the spread of some cancer cells. [10]
Between the ciliated cells are numerous microvilli, attached as tufts to brush cells sometimes referred to as pulmonary brush cells; [9] these are also known as the tuft cells of the gastrointestinal tract, or intestinal tuft cells, [10] although there is a difference between the two types: the brush cells lack the terminal web that lies under ...
The cytoplasmic peripheral protein encoded by this gene can be phosphorylated by protein-tyrosine kinase in microvilli and is a member of the ERM protein family. This protein serves as a linker between plasma membrane and actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. [6]
A 49-year-old grandfather in Southern California said a new drug cured him of his lymphoma after a long battle with the disease.. The newly-approved drug was recently cleared by the US Food and ...
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Fimbrin is present in several distinct structures in different cell types, including intestinal microvilli, hair cell stereocilia and fibroblast filopodia. [7] It is usually associated with polarized actin filaments in membrane ruffles, filopodia, stereocilia and adhesion plaques. Sequence homology and biochemical properties show that fimbrin ...