Ad
related to: tolvaptan vs conivaptan 2 gram cost price chart pdf fillable"The lowest prices on specific drugs" - Family Circle
- GoodRx® Blog
Get the Latest Healthcare News
Find What Matters Most to You
- GoodRx®: Women’s Health
Save on Common Women’s Health Meds.
Find Resources You Can Count On.
- Transparent Pricing
Healthcare is confusing. We make it
simple. Use GoodRx to start saving.
- GoodRx® Press
"Shop wisely with GoodRx"
Featured on CNN & Forbes.
- GoodRx® Blog
Search results
Results from the WOW.Com Content Network
Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan , [ 1 ] [ 2 ] formulated as the salt tolvaptan sodium phosphate, for intravenous administration .
Conivaptan hydrochloride is an off-white or a pale yellow power with a solubility of 0.25 mg/mL in water at 23 °C. The injectable formulation consists of 20 mg conivaptan hydrochloride, 0.4 g ethanol, 1.2 g propylene glycol and water. [2]
Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.
This is followed by Part 2 of the study, during which all study participants who complete Part 1 will receive lixivaptan in a single-arm, open-label phase for an additional 12 months. Part 2 will investigate whether lixivaptan's effect on kidney function continues to accrue over time.
Vasopressin receptor 2 (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor for vasopressin. [5] AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the G s type of G proteins, which stimulate adenylate cyclase.
Nelivaptan [1] (developmental codename SSR-149,415) is a selective, orally active, non-peptide vasopressin receptor antagonist selective for the V 1B subtype. [2] The drug had entered clinical trials for treatment of anxiety and depression. [3] In July 2008, Sanofi-Aventis announced that further development of this drug had been halted. [4]
Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin-2 receptor antagonist [1] which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia. It was also being studied for the treatment of ascites. [2] Development was discontinued in 2009. [3]
Ad
related to: tolvaptan vs conivaptan 2 gram cost price chart pdf fillable"The lowest prices on specific drugs" - Family Circle