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Repeated implantation failure (RIF) is the repeated failure of the embryo to implant onto the side of the uterus wall following IVF treatment. [1] Implantation happens at 6–7 days after conception and involves the embedding of the growing embryo into the mothers uterus and a connection being formed. [2]
The timeline of reciprocal IVF depends on if a couple chooses to undergo a fresh or a frozen transfer: A fresh embryo transfer IVF cycle lasts around 17–20 days and 10 days after the embryo is transferred to wait for the results of a pregnancy test. [14] A frozen embryo transfer first involves one of the cycles dedicated to the genetic mother.
The benefits of using morphokinetics in terms of improving clinical outcomes of IVF is still very unclear. [9] A meta-analysis published in 2017, supported the idea of clinical benefits of time-lapse culture with morphokinetic embryo selection in IVF, reporting reduced early pregnancy loss, higher ongoing pregnancy and higher live birth rates. [13]
Thus, if a clomiphene treatment has a chance to establish a pregnancy in 8% of cycles and costs $780, the expected cost is $9,400 to establish a pregnancy, compared to an IVF cycle (cycle fecundity 40%) with a corresponding expected cost of $46,800 ($18,700 × 40%). [citation needed]
In vitro fertilisation (IVF) is a process of fertilisation in which an egg is combined with sperm in vitro ("in glass"). The process involves monitoring and stimulating a woman's ovulatory process, then removing an ovum or ova (egg or eggs) from her ovaries and enabling a man's sperm to fertilise them in a culture medium in a laboratory.
The technique, first attempted by Steptoe and Edwards [1] and later pioneered by endocrinologist Ricardo Asch, allows fertilization to take place inside the woman's uterus. [ 2 ] With the advances in IVF the GIFT procedure is used less as pregnancy rates in IVF tend to be equal or better and do not require laparoscopy when the egg is put back.
In terms of insemination, ICSI needs only one sperm cell per oocyte, while IVF needs 50,000–100,000. This is because the acrosome reaction has to take place and thousands of sperm cells have to be involved in IVF. Once fertilized, the egg is transformed into a pre-embryo and it has to be transferred to the uterus to continue its development.
[1] In terms of pregnancy rates, live births, or the risk of stillbirth or miscarriage there is a lack of evidence of sufficient quality to know if there is any difference between time-lapse embryo imaging and conventional embryo assessment in in-vitro fertilisation (IVF) . [ 2 ]
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