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If unresolved, continued inflammation can result in irreparable damage such as pulmonary fibrosis. [4] Pneumonitis is distinguished from pneumonia on the basis of causation as well as its manifestation. Pneumonia can be described as pneumonitis combined with consolidation and exudation of lung tissue due to infection with microorganisms. [5]
"Organizing" refers to unresolved pneumonia (in which the alveolar exudate persists and eventually undergoes fibrosis) in which fibrous tissue forms in the alveoli.The phase of resolution and/or remodeling following bacterial infections is commonly referred to as organizing pneumonia, both clinically and pathologically.
A proinflammatory cytokine causes hyperinflammation, the leading cause of lung tissue destruction in cystic fibrosis. [12] With such a strong inflammatory response and an elevated number of immune cells, lungs of cystic fibrosis patients cannot clear the bacteria and become more susceptible to infections.
Chronic systemic inflammation (SI) is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.It can contribute to the development or progression of certain conditions such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune and neurodegenerative ...
Type 2 inflammation is a pattern of immune response. Its physiological function is to defend the body against helminths , but a dysregulation of the type 2 inflammatory response has been implicated in the pathophysiology of several diseases.
Pneumonia is an inflammatory condition of the lung primarily affecting the small air sacs known as alveoli. [3] [14] Symptoms typically include some combination of productive or dry cough, chest pain, fever, and difficulty breathing. [15]
The cholinergic anti-inflammatory pathway provides a braking effect on the innate immune response which protects the body against the damage that can occur if a localized inflammatory response spreads beyond the local tissues, which results in toxicity or damage to the kidney, liver, lungs, and other organs.
The Dietary Inflammatory Index (DII) is a numerical score that assesses a diet for its effect on several biomarkers linked to inflammation. Its theoretical bounds are −8.87 to +7.98, and it is oriented such that negative scores are more anti-inflammatory and more positive scores are pro-inflammatory .
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