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For double bonded molecules, Cahn–Ingold–Prelog priority rules (CIP rules) are followed to determine the priority of substituents of the double bond. If both of the high priority groups are on the same side of the double bond (cis configuration), then the stereoisomer is assigned the configuration Z (zusammen, German word
Absolute configuration uses a set of rules to describe the relative positions of each bond around the chiral center atom. The most common labeling method uses the descriptors R or S and is based on the Cahn–Ingold–Prelog priority rules. R and S refer to rectus and sinister, Latin for right and left, respectively.
The Cahn-Ingold-Prelog (CIP) system uses R and S designations to define the configuration of atoms about any stereocenter. [7] A designation of R denotes a clockwise direction of substituent priority around the stereocenter, while a designation of S denotes a counter-clockwise direction of substituent priority. [7]
The Buergenstock Declaration, signed by Cahn, Ingold, and Prelog, as well as 2 others attending the stereochemistry conference held in Buergenstock, Switzerland in 1966, does not appear to have had any role in "laying down the rules" of the CIP conventions. These were put forth in the articles referenced elsewhere on the page.
Robert Sidney Cahn (9 June 1899 – 15 June 1981) was a British chemist, best known for his contributions to chemical nomenclature and stereochemistry, particularly by the Cahn–Ingold–Prelog priority rules, which he proposed in 1956 with Christopher Kelk Ingold and Vladimir Prelog. [1] Cahn was the first to report the structure of ...
Cahn–Ingold–Prelog priority rules are part of a system for describing a molecule's stereochemistry. They rank the atoms around a stereocenter in a standard way, allowing unambiguous descriptions of their relative positions in the molecule.
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E–Z configuration, or the E–Z convention, is the IUPAC preferred method of describing the absolute stereochemistry of double bonds in organic chemistry.It is an extension of cis–trans isomer notation (which only describes relative stereochemistry) that can be used to describe double bonds having two, three or four substituents.