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Single-stranded DNA is produced during all aspects of DNA metabolism: replication, recombination, and repair. As well as stabilizing this single-stranded DNA, SSB proteins bind to and modulate the function of numerous proteins involved in all of these processes. Active E. coli SSB is composed of four identical 19 kDa subunits. Binding of single ...
In ICP8, the herpes simplex virus (HSV-1) single-strand DNA-binding protein (ssDNA-binding protein (SSB)), the head consists of the eight alpha helices.The front side of the neck region consists of a five-stranded beta-sheet and two alpha helices, whereas the back side is a three-stranded beta-sheet The shoulder part of the N-terminal domain contains an alpha-helical and beta-sheet region. [1]
381760 Ensembl ENSG00000262771 ENSG00000106028 ENSMUSG00000029911 UniProt Q04837 Q9CYR0 RefSeq (mRNA) NM_001256510 NM_001256511 NM_001256512 NM_001256513 NM_003143 NM_001286663 NM_028358 NM_212468 NM_001364578 RefSeq (protein) NP_001243439 NP_001243440 NP_001243441 NP_001243442 NP_003134 NP_001273592 NP_082634 NP_997633 NP_001351507 Location (UCSC) Chr 7: 141.74 – 141.79 Mb Chr 6: 40.45 ...
Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. [ 1 ] [ 2 ] In vitro , RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. [ 3 ]
To counteract this instability, single-strand binding proteins (SSB in prokaryotes and Replication protein A in eukaryotes) bind to the exposed bases to prevent improper ligation. If you consider each strand as a "dynamic, stretchy string", the structural potential for improper ligation should be obvious.
It's way easier—and more special—than a roast. Every holiday spread needs a grand centerpiece. Usually it takes the form of a massive roast or a shiny glazed ham.These impressive (and often ...
The SSB protein interacts with DNA helicases PriA and RecG to recover stalled DNA replication forks. These enzymes must bind to the SSB-helicase to be loaded onto stalled forks. Thermal sliding and DNA duplex binding are possibly supported by the wedge domain of RecG's association with the SSB linker.
A dollop of ricotta adds protein to a store-bought crepe, while the berries give a burst of sweetness and a little fiber. View Recipe. Pesto Scrambled Eggs.