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The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone.
GHRH binding to GHRHR results in increased GH production mainly by the cAMP-dependent pathway, [5] but also by the phospholipase C pathway (IP 3 /DAG pathway), [1] and other minor pathways. [ 1 ] The cAMP-dependent pathway is initiated by the binding of GHRH to its receptor, causing receptor conformation that activates G s alpha subunit of the ...
This gene encodes a protein that is a transmembrane receptor for growth hormone. [10] [11] Binding of growth hormone to the receptor leads to reorientation of a pre-assembled receptor dimer dimerization (the receptor may however also exist as monomers on the cell surface [12]) and the activation of an intra- and intercellular signal transduction pathway leading to growth. [13]
Growth hormone secretagogues or GH secretagogues (GHSs) are a class of drugs which act as secretagogues (i.e., induce the secretion) of growth hormone (GH). [1] They include agonists of the ghrelin/growth hormone secretagogue receptor (GHSR), such as ghrelin (lenomorelin), pralmorelin (GHRP-2), GHRP-6, examorelin (hexarelin), ipamorelin, and ibutamoren (MK-677), [1] [2] and agonists of the ...
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Genes that may be involved include GH1, GHRHR, or BTK. [3] In a third of cases no cause is apparent. [2] The underlying mechanism generally involves problems with the pituitary gland. [2] Some cases are associated with a lack of other pituitary hormones, in which case it is known as combined pituitary hormone deficiency. [4]