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Micro ribonucleic acid (microRNA, miRNA, μRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. [1] Found in plants, animals, and even some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression .
In Drosophila, bantam microRNA works in the epithelial cells where it regulates the growth of dendrites in sensory neurons. [1] The Hippo signaling pathway also tends to be directly linked with the BANTAM microRNA as it regulates it to control the functionality of cell proliferation and survival.
Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as a key tool in gene regulation. [2] The single strand of RNA acts as a template for RISC to recognize complementary messenger RNA (mRNA) transcript .
Ruvkun’s work on the other mutant gene showed that microRNA attached to the RNA made by his mutant gene and acted as a monkey wrench in the protein-making process, essentially blocking its ...
The chemical structure of RNA is very similar ... is a small RNA chain of about 80 nucleotides that transfers a specific amino acid ... RNA Structure, Function, ...
The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. [1]
n/a Ensembl ENSG00000284190 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 17: 59.84 – 59.84 Mb n/a PubMed search n/a Wikidata View/Edit Human microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly ...
MicroRNA molecules are synthesized as long RNA primary transcripts known as a pri-miRNAs, which are cleaved by Drosha to produce a characteristic stem-loop structure of about 70 base pairs long, known as a pre-miRNA. [11] Pre-miRNAs, when associated with EXP5, are stabilized due to removal of the 5' cap and 3' poly(A) tail. [13]