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Time-lapse video of mitosis in a Drosophila melanogaster embryo. The primary result of mitosis and cytokinesis is the transfer of a parent cell's genome into two daughter cells. The genome is composed of a number of chromosomes—complexes of tightly coiled DNA that contain genetic information vital for proper cell function. [32]
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
The presence of these core cell cycle factors can be explained through their role in neuronal migration, maturation, and synaptic plasticity (Christopher L. Frank1 and Li-Huei Tsai1, 2009). However, it is also possible that, under certain conditions, these factors can induce cell cycle re-entry.
[5] [6] After growth from the zygote to the adult, cell division by mitosis allows for continual construction and repair of the organism. [7] The human body experiences about 10 quadrillion cell divisions in a lifetime. [8] The primary concern of cell division is the maintenance of the original cell's genome.
Schematic karyogram of the human chromosomes, showing their usual state in the G 0 and G 1 phase of the cell cycle. At top center it also shows the chromosome 3 pair in metaphase (annotated as "Meta."), which takes place after having undergone DNA synthesis which occurs in the S phase (annotated as S) of the cell cycle.
Mitosis divides the chromosomes in a cell nucleus. During mitosis chromosome segregation occurs routinely as a step in cell division (see mitosis diagram). As indicated in the mitosis diagram, mitosis is preceded by a round of DNA replication, so that each chromosome forms two copies called chromatids.
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Prometaphase is the phase of mitosis following prophase and preceding metaphase in eukaryotic somatic cells.In prometaphase, the nuclear membrane breaks apart into numerous "membrane vesicles," and the chromosomes inside form protein structures called kinetochores. [1]