Search results
Results from the WOW.Com Content Network
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. [1] If the cell grows uncontrollably, it will result in cancer . When a tumor suppressor gene is mutated, it results in a loss or reduction in its function.
Under this model, cancer arises as the result of a single, isolated event, rather than the slow accumulation of multiple mutations. [4] The exact function of some tumor suppressor genes is not currently known (e.g. MEN1, WT1), [5] but based on these genes following the Knudson "two-hit" hypothesis, they are strongly presumed to be suppressor genes.
To tightly control cell division, cells have processes within them that prevent cell growth and division. These processes are orchestrated by proteins encoded by tumor suppressor genes. These genes take information from the cell to ensure that it is ready to divide, and will halt division if not (when the DNA is damaged, for example). In cancer ...
13176 Ensembl ENSG00000187323 ENSMUSG00000060534 UniProt P43146 P70211 RefSeq (mRNA) NM_005215 NM_007831 RefSeq (protein) NP_005206 NP_031857 Location (UCSC) Chr 18: 52.34 – 53.54 Mb Chr 18: 71.39 – 72.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene ...
TP-53 is a gene that encodes for the protein p53; this protein is a tumor suppressor. p53 was discovered in 1979 stemming from a study involving cancer immunology and the role of viruses in some cancers. The protein was so named because it was measured to have a weight of 53 kDa.
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
[1] [2] Gene silencing can occur during either transcription or translation and is often used in research. [1] [2] In particular, methods used to silence genes are being increasingly used to produce therapeutics to combat cancer and other diseases, such as infectious diseases and neurodegenerative disorders.
SDPR functions as a metastasis suppressor in breast cancer, potentially by priming cells to apoptosis. [8] Cancer cells suppress the gene via promoter DNA methylation hence exemplifies the significance of epigenetic changes in cancer progression. [9] [10] KISS1 is found in melanoma and breast cancers. It acts by synthesizing a protein receptor.