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  2. Diazepam - Wikipedia

    en.wikipedia.org/wiki/Diazepam

    Diazepam does not possess any chiral centers in its structure, but it does have two conformers.The two conformers mentioned were the 'P'-conformer and 'M'-conformer. Diazepam is an equimolar mixture and it was shown through CD spectra in serum protein solutions, that the 'P'-conformer is preferred by α1-acid glycoprotein b

  3. List of drugs by year of discovery - Wikipedia

    en.wikipedia.org/wiki/List_of_drugs_by_year_of...

    Opioids are among the world's oldest known drugs. [13] [14] Use of the opium poppy for medical, recreational, and religious purposes can be traced to the 4th century BCE, when Hippocrates wrote about it for its analgesic properties, stating, "Divinum opus est sedare dolores." ("Divine work is the easing of pain") [15]

  4. Benzodiazepine - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine

    Tizanidine has been found to have superior tolerability compared to diazepam and baclofen. [72] Benzodiazepines are also used to treat the acute panic caused by hallucinogen intoxication. [73] Benzodiazepines are also used to calm the acutely agitated individual and can, if required, be given via an intramuscular injection. [74]

  5. List of benzodiazepines - Wikipedia

    en.wikipedia.org/wiki/List_of_benzodiazepines

    The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.

  6. Diazepam Nasal Spray Demonstrates Comparable Bioavailability ...

    www.aol.com/news/2013-03-20-diazepam-nasal-spray...

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  7. Leo Sternbach - Wikipedia

    en.wikipedia.org/wiki/Leo_Sternbach

    Librium, based on the R0 6-690 compound discovered by Sternbach in 1956, was approved for use in 1960. In 1963, its improved version, Valium, was released and became astonishingly popular: between 1969 and 1982, it was the most prescribed drug in America, with over 2.3 billion doses sold in its peak year of 1978.

  8. Timeline of scientific discoveries - Wikipedia

    en.wikipedia.org/wiki/Timeline_of_scientific...

    The following dates are approximations. 700 BC: Pythagoras's theorem is discovered by Baudhayana in the Hindu Shulba Sutras in Upanishadic India. [18] However, Indian mathematics, especially North Indian mathematics, generally did not have a tradition of communicating proofs, and it is not fully certain that Baudhayana or Apastamba knew of a proof.

  9. Depressant - Wikipedia

    en.wikipedia.org/wiki/Depressant

    The first such drug, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and made available in 1960 by Hoffmann–La Roche, which has also marketed the benzodiazepine diazepam (Valium) since 1963. Xanax 2 mg tri-score tablets, a classical benzodiazepine sedative

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