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Diazepam can substitute for the behavioral effects of barbiturates in a primate study. [129] Diazepam has been found as an adulterant in heroin. [130] Diazepam drug misuse can occur either through recreational misuse where the drug is taken to achieve a high or when the drug is continued long term against medical advice. [131]
Opioids are among the world's oldest known drugs. [13] [14] Use of the opium poppy for medical, recreational, and religious purposes can be traced to the 4th century BCE, when Hippocrates wrote about it for its analgesic properties, stating, "Divinum opus est sedare dolores." ("Divine work is the easing of pain") [15]
Like diazepam it has a long elimination half-life and long-acting active metabolites. Discontinuation of benzodiazepines or abrupt reduction of the dose, even after a relatively short course of treatment (two to four weeks), may result in two groups of symptoms, rebound and withdrawal. Rebound symptoms are the return of the symptoms for which ...
Librium, based on the R0 6-690 compound discovered by Sternbach in 1956, was approved for use in 1960. In 1963, its improved version, Valium, was released and became astonishingly popular: between 1969 and 1982, it was the most prescribed drug in America, with over 2.3 billion doses sold in its peak year of 1978.
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
The timeline begins at the Bronze Age, as it is difficult to give even estimates for the timing of events prior to this, such as of the discovery of counting, natural numbers and arithmetic. To avoid overlap with timeline of historic inventions , the timeline does not list examples of documentation for manufactured substances and devices unless ...
This is a full timeline of Kate’s health journey since January 2024. 16 January, Tuesday The Princess’s saga begins in January when she is secretly admitted to The London Clinic for abdominal ...
These timelines of world history detail recorded events since the creation of writing roughly 5000 years ago to the present day. For events from c. 3200 BC – c. 500 see: Timeline of ancient history; For events from c. 500 – c. 1499, see: Timeline of post-classical history; For events from c. 1500, see: Timelines of modern history