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Because pernicious anemia is due to a lack of intrinsic factor, it is not preventable. [11] Pernicious anemia can be treated with injections of vitamin B 12. [7] If the symptoms are serious, frequent injections are typically recommended initially. [7] There are not enough studies that pills are effective in improving or eliminating symptoms. [12]
Pernicious anemia is the most common cause of vitamin B 12 deficiency anemia in adults, which results from malabsorption of vitamin B 12 due to a lack or loss of intrinsic factor. [ 2 ] [ 8 ] There are relatively few studies which have assessed the impact of haematological measures in response to B 12 supplementation.
Despite the low amounts absorbed, oral vitamin B 12 therapy is effective at reducing symptoms of pernicious anemia. [22] Vitamin B 12 can also be given sublingually, but there is no evidence that this route of administration is superior to the oral route, [23] and only Canada and Sweden routinely prescribe this route of administration. [20]
During the 1920s, George Whipple discovered that ingesting large amounts of raw liver seemed to most rapidly cure the anemia of blood loss in dogs, and hypothesized that eating liver might treat pernicious anemia. [142] Edwin Cohn prepared a liver extract that was 50 to 100 times more potent in treating pernicious anemia than the natural liver ...
The most common are pernicious anemia possibly leading to vitamin B 12 deficiency; and malabsorption of iron, leading to iron deficiency anaemia. [2] It can be caused by persistent infection with Helicobacter pylori, or can be autoimmune in origin.
Pernicious anemia: D51.0: 9870: Pernicious anemia (also known as macrocytic achylic anemia, congenital pernicious anemia, juvenile pernicious anemia, and Vitamin B12 deficiency) is one of many types of the larger family of megaloblastic anemias. It is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B 12.
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