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Alogabat (INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name; developmental code names RG-7816 and RO7017773) is an α 5 subunit-containing GABA A receptor positive allosteric modulator which is under development for the treatment of pervasive developmental disorders (e.g., autism) and Angelman syndrome.
[2] [3] [4] The pathway is a minor pathway in GABA synthesis compared to the main pathway in which GABA is synthesized from glutamate. [ 2 ] [ 3 ] [ 4 ] However, the pathway has been found to have an important physiological role in the brain, for instance in the production of GABA in the striatum and resultant inhibition of dopaminergic neurons ...
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]
[2] [3] [4] The pathway is a minor pathway in GABA synthesis compared to the main pathway in which GABA is synthesized from glutamate. [ 2 ] [ 3 ] [ 4 ] However, the pathway has been found to have an important physiological role in the brain, for instance in the production of GABA in the striatum and resultant inhibition of dopaminergic neurons ...
Vigabatrin is an irreversible mechanism-based inhibitor of gamma-aminobutyric acid aminotransferase (GABA-AT), the enzyme responsible for the catabolism of GABA. Inhibition of GABA-AT results in increased levels of GABA in the brain. [7] [26] Vigabatrin is a racemic compound, and its [S]-enantiomer is pharmacologically active. [27], [28]
Image credits: tyrion2024 #3. TIL that more than half the drop in America’s total fertility rate is explained by women under the age of 19 now having next to no children.
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