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Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
The experiment demonstrated conclusively that beriberi was a deficiency disease rather than the result of a toxin in the mother's milk. In 1913 Vedder published a seminal book on the subject. In 1913, Vedder returned to the United States and was appointed assistant professor of pathology at the Army Medical School in Washington D.C.
The group that ate only white rice documented 161 crew members with beriberi and 25 deaths, while the latter group had only 14 cases of beriberi and no deaths. This convinced Takaki and the Japanese Navy that diet was the cause of beriberi, but they mistakenly believed that sufficient amounts of protein prevented it. [65]
Adolphe Guillaume Vorderman (12 December 1844 – 15 July 1902) was a Dutch physician and scientist whose study [1] of the link between polished rice and beriberi in the Dutch East Indies in 1897 helped lead to the discovery of vitamins.
Thiamine deficiency, in particular, is common in people with alcohol use disorder and can lead to a condition known as beriberi, which can damage the heart muscle. [4] Furthermore, chronic alcohol consumption can also lead to other cardiovascular risk factors, such as high blood pressure, high cholesterol levels, and obesity, which can ...
Baron Takaki Kanehiro (高木 兼寛, 30 October 1849 – 12 April 1920) was a Japanese naval physician.He is known for his work on preventing the vitamin deficiency disease beriberi among sailors in the Japanese navy, who had been living mainly on white rice.
Deficiency of vitamin B 1, thiamine, causes beriberi which can be associated with a painful sensory neuropathy with muscle weakness and atrophy. Deficiency of niacine, vitamin B 3 , causes pellagra which can present with various peripheral neuropathies in addition to keratotic skin lesions.
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