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Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
14560 Ensembl ENSG00000266524 ENSMUSG00000021943 UniProt P55107 P97737 RefSeq (mRNA) NM_004962 NM_145741 RefSeq (protein) NP_004953 NP_665684 Location (UCSC) Chr 10: 47.3 – 47.31 Mb Chr 14: 33.65 – 33.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is ...
12156 Ensembl ENSG00000125845 ENSMUSG00000027358 UniProt P12643 P21274 RefSeq (mRNA) NM_001200 NM_007553 RefSeq (protein) NP_001191 NP_031579 Location (UCSC) Chr 20: 6.77 – 6.78 Mb Chr 2: 133.39 – 133.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. Function BMP-2 like other bone morphogenetic ...
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. [5] GDF11 is a member of the Transforming growth factor beta family. [6] GDF11 acts as a cytokine and its sequence is highly conserved between in humans, mice and ...
2658 12165 Ensembl ENSG00000263761 ENSMUSG00000072625 UniProt Q9UK05 Q9WV56 RefSeq (mRNA) NM_016204 NM_019506 RefSeq (protein) NP_057288 NP_062379 Location (UCSC) Chr 10: 47.32 – 47.33 Mb Chr 14: 33.66 – 33.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is ...
A metabologen is defined as a morphogen (molecule) that can initiate, promote and maintain metabolism and homeostasis.Based on this definition, bone morphogenetic proteins (BMPs) are metabologens, since they are involved in iron homeostasis, brown fat adipogenesis and energy metabolism.
GDF6 interacts with bone morphogenetic proteins to regulate ectoderm patterning, and controls eye development. [11] [12] [13] GDF8 is now officially known as myostatin and controls the growth of muscle tissue. [14] GDF9, like GDF3, lacks one cysteine relative to other members of the TGF-β superfamily.
Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene. [5] [6] [7] The protein encoded by this gene is closely related to the bone morphogenetic protein (BMP) family and is a member of the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved ...