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Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
12156 Ensembl ENSG00000125845 ENSMUSG00000027358 UniProt P12643 P21274 RefSeq (mRNA) NM_001200 NM_007553 RefSeq (protein) NP_001191 NP_031579 Location (UCSC) Chr 20: 6.77 – 6.78 Mb Chr 2: 133.39 – 133.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. Function BMP-2 like other bone morphogenetic ...
2658 12165 Ensembl ENSG00000263761 ENSMUSG00000072625 UniProt Q9UK05 Q9WV56 RefSeq (mRNA) NM_016204 NM_019506 RefSeq (protein) NP_057288 NP_062379 Location (UCSC) Chr 10: 47.32 – 47.33 Mb Chr 14: 33.66 – 33.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is ...
A bone growth factor is a growth factor that stimulates the growth of bone tissue. [1] [2]Known bone growth factors include insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid hormone-related peptide (PTHrP), bone morphogenetic proteins (BMPs ...
A metabologen is defined as a morphogen (molecule) that can initiate, promote and maintain metabolism and homeostasis.Based on this definition, bone morphogenetic proteins (BMPs) are metabologens, since they are involved in iron homeostasis, brown fat adipogenesis and energy metabolism.
Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. [4] [5] BMP4 is found on chromosome 14q22-q23. BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. BMP4 is highly ...
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. [5] GDF11 is a member of the Transforming growth factor beta family. [6] GDF11 acts as a cytokine and its sequence is highly conserved between in humans, mice and ...
Morphogenesis of Drosophila fruit flies is intensively studied in the laboratory. A morphogen is a substance whose non-uniform distribution governs the pattern of tissue development in the process of morphogenesis or pattern formation, one of the core processes of developmental biology, establishing positions of the various specialized cell types within a tissue.