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Ninety-six percent of patients with lupus induced by procainamide will have a positive test for anti-histone antibodies, and 100% of patients whose lupus was induced by penicillamine, isoniazid, or methyldopa will have a positive test for anti-histone antibodies. In 70% of patients with rheumatoid arthritis, Felty's syndrome, Sjogren's syndrome ...
[10] [11] However, CPP crystals are much better known for their rhomboid shape and weak positive birefringence on polarized light microscopy, and this method remains the most reliable method of identifying the crystals under the microscope. [12] However, even this method has poor sensitivity, specificity, and inter-operator agreement. [12]
Rheumatoid factor is part of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis. RF positivity combines well with anti-CCP and/or 14-3-3η to inform diagnosis. [9] RF positivity at baseline has also been described as a good prognostic marker for future radiographic damage. [10]
The typical rheumatoid nodule may be a few millimetres to a few centimetres in diameter and is usually found over bony prominences, such as the elbow, the heel, the knuckles, or other areas that sustain repeated mechanical stress. Nodules are associated with a positive RF (rheumatoid factor) titer, ACPA, and severe erosive arthritis. Rarely ...
[1] [12] [13] [14] This subtype begins later in childhood and could be subdivided into two types: Rheumatoid Factor (RF) negative and RF positive depending on the presence of the RF antibody. Typically five or more joints are affected during the first six months (usually smaller joints such as the hands and feet but many also affect the hips ...
Their significance is greater than that of rheumatoid factor. Recently a serological point-of-care test (POCT) for the early detection of RA has been developed. This assay combines the detection of rheumatoid factor and anti-MCV for diagnosis of rheumatoid arthritis and shows a sensitivity of 72% and specificity of 99.7%. [4] [5]
Palindromic rheumatism is a disease of unknown cause. It has been suggested that it is an abortive form of rheumatoid arthritis (RA), since anti-cyclic citrullinated peptide antibodies (anti-CCP) and antikeratin antibodies (AKA) are present in a high proportion of patients, as is the case in rheumatoid arthritis. [6]
Download QR code; Print/export ... Rheumatoid factor (RF) < 20: 20–30 > 30 ... Low/weak positive Moderate positive High/strong positive