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Other causes of peptic ulcer disease include gastric ischaemia, drugs, metabolic disturbances, cytomegalovirus (CMV), upper abdominal radiotherapy, Crohn's disease, and vasculitis. [16] Gastrinomas ( Zollinger–Ellison syndrome ), or rare gastrin-secreting tumors, also cause multiple and difficult-to-heal ulcers.
Mucosal disruption in acid peptic disease patients can be caused by infection, barrier disruption, or gastric acid hypersecretion.Acid peptic diseases can arise due to various risk factors such as Helicobacter pylori infection, alcoholism, tobacco use, cocaine and amphetamine use, nonsteroidal anti-inflammatory drug use (NSAIDs), fasting, Zollinger-Ellison syndrome, angiogenesis inhibitor ...
This is a timeline of the events relating to the discovery that peptic ulcer disease and some cancers are caused by H. pylori. In 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Physiology or Medicine for their discovery that peptic ulcer disease (PUD) was primarily caused by Helicobacter pylori , a bacterium with affinity ...
Peptic ulcer disease, a wearing away of the stomach lining, can be asymptomatic in some cases, but others are severe enough to make a patient double over in pain, two doctors said.
In people with a confirmed peptic ulcer, proton pump inhibitors do not reduce death rates, later bleeding events, or need for surgery. [18] They may decrease signs of bleeding at endoscopy however. [18] In those with less severe disease and where endoscopy is rapidly available, they are of less immediate clinical importance. [16]
The causes are divided into benign or malignant. Benign Peptic ulcer disease; Infections, such as tuberculosis; and infiltrative diseases, such as amyloidosis.; A rare cause of gastric outlet obstruction is blockage with a gallstone, also termed "Bouveret syndrome" or "Bouveret's syndrome".
Indigestion is a diagnosis related to a combination of symptoms that can be attributed to "organic" or "functional" causes. [13] Organic dyspepsia should have pathological findings upon endoscopy, like an ulcer in the stomach lining in peptic ulcer disease. [13]
Cranberry consumption may help suppress a type of bacteria that causes peptic ulcers, which can lead to stomach cancer, explains Lauren Manaker M.S., R.D.N., L.D.