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Glioblastoma, previously known as glioblastoma multiforme (GBM), is the most aggressive and most common type of cancer that originates in the brain, and has a very poor prognosis for survival. [ 6 ] [ 7 ] [ 8 ] Initial signs and symptoms of glioblastoma are nonspecific. [ 1 ]
Gliosarcoma is a malignant cancer, and is defined as a glioblastoma consisting of gliomatous and sarcomatous components. [3] Primary gliosarcoma (PGS) is classified as a grade IV tumor and a subtype of glioblastoma multiforme in the 2007 World Health Organization classification system (GBM). [4]
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor, accounting for about 15% of all primary malignant brain tumors. ... This is also true for pediatric high-grade gliomas ...
Macroscopic pathology of glioblastoma. The Kernohan grading system [5] [6] defines progressive malignancy of astrocytomas as follows: Grade 1 tumors are benign astrocytomas. Grade 2 tumors are low-grade astrocytomas. Grade 3 tumors are anaplastic astrocytomas. Grade 4 tumors are glioblastomas.
For low-grade tumors, the prognosis is somewhat more optimistic. Patients diagnosed with a low-grade glioma are 17 times as likely to die as matched patients in the general population. [82] The age-standardized 10-year relative survival rate was 47% according to research in 2014. [82]
The prognosis of brain cancer depends on the type of cancer diagnosed. Medulloblastoma has a good prognosis with chemotherapy, radiotherapy, and surgical resection while glioblastoma has a median survival of only 15 months even with aggressive chemoradiotherapy and surgery. [82]
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