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Ganglioneuroma (occasionally called a "ganglioma") is a rare and benign tumor of the autonomic nerve fibers arising from neural crest sympathogonia (undifferentiated cells of the sympathetic nervous system). [1] However, ganglioneuromas themselves are fully differentiated neuronal tumors that do not contain immature elements. [2]
Ganglioneuroma (benign) Ganglioneuroblastoma (intermediate). Neuroblastoma (aggressive) See also. Neuroblastoma; References External links. This page was last edited ...
Ganglioneuroma - a tumor of the sympathetic nerve fibers arising from neural crest cells. [ 4 ] Pacinian neuroma - a very rare, painful, benign hyperplastic tumor of Pacinian corpuscles ( mechanoreceptors responsible for sensitivity to vibration and pressure ), sometimes linked to a history of local trauma .
For instance, the Schwann cell, which is the major neoplastic cell component of neurofibroma, [7] is cytologically distinguished by the expression of S-100 protein and wavy nuclear outlines. [ 8 ] [ 9 ] A variety of peripheral nerve cells, including axons, perineurial cells, fibroblasts, and varying inflammatory components such as mast cells ...
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Histologically, ganglioglioma is composed of both neoplastic glial and ganglion cells which are disorganized, variably cellular, and non-infiltrative. Occasionally, it may be challenging to differentiate ganglion cell tumors from an infiltrating glioma with entrapped neurons.
Currently, as of 2023, clinicians are using the 5th edition, which incorporates recent advances in molecular pathology. [1] The books lists ICD-O codes, CNS WHO grades and describes epidemiological, clinical, macroscopic and histopathological features, among others. [2] The following is a simplified (deprecated) version of the fifth edition.
Malignant peripheral nerve sheath tumor. Back skin, 65-year-old man. MPNST. Symptoms may include: Swelling in the extremities (arms or legs), also called peripheral edema; the swelling often is painless.