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Detectors in the PET scanner detect the radioactivity as the compound charges in various regions of the brain. A computer uses the data gathered by the detectors to create multi-dimensional (normally 3-dimensional volumetric or 4-dimensional time-varying) images that show the distribution of the radiotracer in the brain following the time.
Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. ARIA is associated with anti-amyloid drugs, particularly human monoclonal antibodies such as aducanumab. [1] There are two types of ARIA: ARIA-E and ARIA-H.
Amyloid beta immunostaining showing amyloid plaques (brown) Amyloid plaques (also known as neuritic plaques , amyloid beta plaques or senile plaques ) are extracellular deposits of amyloid beta (Aβ) protein that present mainly in the grey matter of the brain.
Pittsburgh compound B (PiB) is a radioactive analog of thioflavin T, which can be used in positron emission tomography scans to image beta-amyloid plaques in neuronal tissue. Due to this property, Pittsburgh compound B may be used in investigational studies of Alzheimer's disease .
New research shows that glial cells play an important role in producing amyloid beta, a protein linked to Alzheimer’s disease. The study, undertaken by scientists at the Max Planck Institute ...
After a rejection last year, the Food and Drug Administration approved Amyvid, a dye for detecting beta-amyloid plaques in Alzheimer's. Eli Lilly's (NYS: LLY) 2010 purchase of Avid ...
In vivo magnetic resonance spectroscopy (MRS) is a specialized technique associated with magnetic resonance imaging (MRI). [1] [2]Magnetic resonance spectroscopy (MRS), also known as nuclear magnetic resonance (NMR) spectroscopy, is a non-invasive, ionizing-radiation-free analytical technique that has been used to study metabolic changes in brain tumors, strokes, seizure disorders, Alzheimer's ...
Getting rid of amyloid plaques has failed to help patients with dementia so scientists are looking for new treatment targets. As new Alzheimer’s drugs have failed, scientists are shifting focus ...
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