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The data suggest that clozapine may be more likely to cause adverse metabolic effects than some of the other atypical antipsychotics. [189] For people who gain weight because of clozapine, taking metformin may reportedly improve three of the five components of the metabolic syndrome: waist circumference, fasting glucose, and fasting triglycerides.
In a meta-analysis of 18 antipsychotics, olanzapine and clozapine exhibited the worst metabolic parameters and aripiprazole, brexpiprazole, cariprazine, lurasidone, and ziprasidone the most benign parameters. [70] Aripiprazole, asenapine, ziprasidone and lurasidone have low propensity to cause weight gain. [71]
10. You're taking medications that cause weight gain "Certain medications can induce weight gain or hinder weight loss by altering hormones, changing appetite, or causing water retention," says Costa.
Tends to produce less extrapyramidal side effects than typical antipsychotics but more extrapyramidal side effects than sertindole, clozapine and quetiapine. [9] [10] Mild and transient constipation and xerostomia (dry mouth) [citation needed] Dizziness [citation needed] Weight gain of over 15% of one's initial body weight.
“There are many medications that may cause weight gain,” says W. Scott Butsch, M.D., director of obesity medicine in the Bariatric and Metabolic Institute at the Cleveland Clinic.
However, many are associated with an infamous side effect: weight gain. Luckily, some antidepressants are less likely to cause weight gain than others. In fact, there are even some antidepressants ...
Very rarely antipsychotics may cause tardive psychosis. [114] Clozapine is associated with side effects that include weight gain, tiredness, and hypersalivation. More serious adverse effects include seizures, NMS, neutropenia, and agranulocytosis (lowered white blood cell count) and its use needs careful monitoring. [115] [116]
Many common antidepressants can cause weight gain over time, but that's not a reason to avoid taking medication for mental health issues, experts say. - Joe Raedle/Getty Images/File