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Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
"Vitamin K plays a crucial role in producing four of the 13 clotting factors found within the body," Whitaker says. "Without enough vitamin K, clotting may be impaired." "Without enough vitamin K ...
5627 19128 Ensembl ENSG00000184500 ENSMUSG00000022912 UniProt P07225 Q08761 RefSeq (mRNA) NM_000313 NM_001314077 NM_011173 RefSeq (protein) NP_000304 NP_001301006 NP_035303 Location (UCSC) Chr 3: 93.87 – 93.98 Mb Chr 16: 62.67 – 62.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein S (also known as PROS) is a vitamin K -dependent plasma glycoprotein synthesized in the ...
Vitamin K (phylloquinones, menaquinones, and menadiones) Some sources include a fourteenth, choline. [6] Vitamins have diverse biochemical functions. Vitamin A acts as a regulator of cell and tissue growth and differentiation. Vitamin D provides a hormone-like function, regulating mineral metabolism for bones and other organs.
“Vitamin K is a fat-soluble vitamin, so your body stores it in fat tissue and the liver,” Heather Viola, DO, Primary Care Physician at Mount Sinai Doctors-Ansonia, tells Fortune.
Vitamin K deficiency from other causes (e.g., in malabsorption) or impaired vitamin K metabolism in disease (e.g., in liver failure) lead to the formation of PIVKAs (proteins formed in vitamin K absence), which are partially or totally non-gamma carboxylated, affecting the coagulation factors' ability to bind to phospholipid.
The availability of reduced vitamin K is of importance for activation vitamin K 2,3-epoxide. The reduction of vitamin K epoxide is then responsible for the carboxylation of glutamic acid residues in some blood-clotting proteins, including factor VII, factor IX, and factor X. [5] [7] VKORC1 is of therapeutic interest both for its role in ...
VKAs diminish vitamin K levels in the body and inhibit the synthesis of vitamin K dependent clotting factors. [27] Thus, by inhibiting vitamin K, a key element by which the body produces clots, the risk of prolonged bleeding increases. [28] Traditionally, vitamin K has been used as a reversal agent for VKAs.