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  2. Thrombocytopenia - Wikipedia

    en.wikipedia.org/wiki/Thrombocytopenia

    In hematology, thrombocytopenia is a condition characterized by abnormally low levels of platelets ... Warfarin is not recommended until platelets have normalized.

  3. Heparin-induced thrombocytopenia - Wikipedia

    en.wikipedia.org/wiki/Heparin-induced...

    Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin, an anticoagulant. HIT predisposes to thrombosis (the abnormal formation of blood clots inside a blood vessel ).

  4. Warfarin - Wikipedia

    en.wikipedia.org/wiki/Warfarin

    Warfarin should not be given to people with heparin-induced thrombocytopenia until platelet count has improved or normalised. [39] Warfarin is usually best avoided in people with protein C or protein S deficiency, as these thrombophilic conditions increase the risk of skin necrosis, which is a rare but serious side effect associated with ...

  5. Prothrombin time - Wikipedia

    en.wikipedia.org/wiki/Prothrombin_time

    The normal range for a healthy person not using warfarin is 0.8–1.2, and for people on warfarin therapy an INR of 2.0–3.0 is usually targeted, although the target INR may be higher in particular situations, such as for those with a mechanical heart valve. If the INR is outside the target range, a high INR indicates a higher risk of bleeding ...

  6. Heparin - Wikipedia

    en.wikipedia.org/wiki/Heparin

    The use of LMWH has allowed once-daily dosing, thus not requiring a continuous infusion of the drug. If long-term anticoagulation is required, heparin is often used only to commence anticoagulation therapy until an oral anticoagulant e.g. warfarin takes effect. The American College of Chest Physicians publishes clinical guidelines on heparin ...

  7. Argatroban - Wikipedia

    en.wikipedia.org/wiki/Argatroban

    Argatroban is used as an anticoagulant in individuals with thrombosis and heparin-induced thrombocytopenia. Often these individuals require long-term anticoagulation. If warfarin is chosen as the long-term anticoagulant, this poses particular challenges due to the falsely elevated prothrombin time and INR caused by argatroban.

  8. Low-molecular-weight heparin - Wikipedia

    en.wikipedia.org/wiki/Low-molecular-weight_heparin

    The use of LMWHs should be avoided in patients with known allergies to LMWHs, heparin, sulfites or benzyl alcohol, in patients with active major bleeding, or in patients with a history of heparin-induced low blood platelet count (also known as heparin-induced thrombocytopenia or HIT). High treatment doses are contraindicated in acute bleeding ...

  9. Prothrombin complex concentrate - Wikipedia

    en.wikipedia.org/wiki/Prothrombin_complex...

    Platelet factor 4 can cause heparin-induced thrombocytopenia. The package insert states that prothrombin complex concentrate is contraindicated in patients with disseminated intravascular coagulation, a pathological activation of coagulation, [24] because giving clotting factors would only further fuel this process. However, if the PCC is given ...

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