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Estrogen dosages for prostate cancer; Route/form Estrogen Dosage Ref(s) Oral: Estradiol: 1–2 mg 3x/day [1] ... Transdermal patch: Estradiol: 2–6x 100 μg/day
Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer. [14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL).
The Prostate Adenocarcinoma: TransCutaneous Hormones (PATCH) study is a large randomized controlled trial in the United Kingdom of high-dose transdermal estradiol patches versus gonadotropin-releasing hormone agonist therapy in the treatment of prostate cancer in men.
High-dose estrogen therapy is used in the treatment of prostate cancer. [52] Estrogens that have been used include diethylstilbestrol , fosfestrol , ethinylestradiol , ethinylestradiol sulfonate , polyestradiol phosphate , and estradiol undecylate , as well as the dual estrogenic and cytostatic agent estramustine phosphate .
Response rates with EMP in prostate cancer are said to be equivalent to conventional high-dose estrogen therapy. [18] Due to its relatively severe side effects and toxicity, EMP has rarely been used in the treatment of prostate cancer. [4] This is especially true in Western countries today. [4]
Polyestradiol phosphate (PEP), sold under the brand name Estradurin, is an estrogen medication which is used primarily in the treatment of prostate cancer in men. [1] [9] [2] [10] It is also used in women to treat breast cancer, as a component of hormone therapy to treat low estrogen levels and menopausal symptoms, and as a component of feminizing hormone therapy for transgender women.
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