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Estrogen dosages for prostate cancer; Route/form Estrogen Dosage Ref(s) Oral: Estradiol: 1–2 mg 3x/day [1] Conjugated estrogens: 1.25–2.5 mg 3x/day [2] [3] Ethinylestradiol: 0.15–3 mg/day [2] [3] [4] Ethinylestradiol sulfonate: 1–2 mg 1x/week [5] [3] [6] Diethylstilbestrol: 1–3 mg/day [2] [7] Dienestrol: 5 mg/day [8] Hexestrol: 5 mg ...
Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer. [14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL).
The Prostate Adenocarcinoma: TransCutaneous Hormones (PATCH) study is a large randomized controlled trial in the United Kingdom of high-dose transdermal estradiol patches versus gonadotropin-releasing hormone agonist therapy in the treatment of prostate cancer in men.
High-dose estrogen therapy is used in the treatment of prostate cancer. [52] Estrogens that have been used include diethylstilbestrol , fosfestrol , ethinylestradiol , ethinylestradiol sulfonate , polyestradiol phosphate , and estradiol undecylate , as well as the dual estrogenic and cytostatic agent estramustine phosphate .
Polyestradiol phosphate (PEP), sold under the brand name Estradurin, is an estrogen medication which is used primarily in the treatment of prostate cancer in men. [1] [9] [2] [10] It is also used in women to treat breast cancer, as a component of hormone therapy to treat low estrogen levels and menopausal symptoms, and as a component of feminizing hormone therapy for transgender women.
A dosage of two to six 100 μg/day transdermal estradiol patches can achieve mean levels of estradiol in the area of 200 to 400 pg/mL and can be used as a form of high-dose estrogen therapy, for instance to suppress testosterone levels in the treatment of prostate cancer in men and in feminizing hormone therapy for transgender women.
[17] [5] [1] [10] The medication is usually reserved for use in hormone-refractory cases of prostate cancer, although it has been used as a first-line monotherapy as well. [3] Response rates with EMP in prostate cancer are said to be equivalent to conventional high-dose estrogen therapy. [18]
Esterified estrogens (EEs), sold under the brand names Estratab and Menest among others, is an estrogen medication which is used hormone therapy for menopausal symptoms and low sex hormone levels in women, to treat breast cancer in both women and men, and to treat prostate cancer in men.
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