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The old dose for pyrazinamide was 40–70 mg/kg daily and the incidence of drug-induced hepatitis has fallen significantly since the recommended dose has been reduced to 12–30 mg/kg daily. In the standard four-drug regimen (isoniazid, rifampicin, pyrazinamide, ethambutol ), pyrazinamide is the most common cause of drug-induced hepatitis. [ 13 ]
The dose for TB meningitis is dexamethasone 8 to 12 mg daily tapered off over six weeks (for those who prefer more precise dosing should refer to Thwaites et al., 2004 [34]). The dose for pericarditis is prednisolone 60 mg daily tapered off over four to eight weeks.
[3] [4] Long-term use may cause yellowing of nails. [7] Phenazopyridine should be avoided by people with glucose-6-phosphate dehydrogenase deficiency, [4] [8] [9] [10] because it can cause hemolysis (destruction of red blood cells) due to oxidative stress. [11] It has been reported to cause methemoglobinemia after overdose and even normal doses ...
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A shorter 2-month course of rifampicin and pyrazinamide had previously been recommended but is no longer recommended due to high rates of hepatotoxicity. [16] Rifampicin should be taken on an empty stomach with a glass of water. It is generally taken either at least one hour before meals or two hours after meals. [17]
Set aside 20 to 30 minutes each week to practice mindfulness and take in the environment around you—without phones, music, TV, or other distractions. Related: 6 Easy Ways to Practice Mindfulness ...
The family of missing Hawaiian photographer Hannah Kobayashi says two suspicious Venmo payments she made to a man and woman around the time she vanished are being investigated by cops.
[5] Tizanidine demonstrates anti-hypertensive effects and should be avoided in patients taking isradipine due to the possibility of synergism between both medications. [6] The antibiotic rifampin lowered plasma concentrations of isradipine to below detectable limits. [2] Cimetidine increased isradipine mean peak plasma levels.