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Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1]
In the 1930s, he contributed significantly to finding a cure for pellagra, a nutritional disease that once afflicted millions in the American South. Later, he also made a large contribution to finding cure for tropical sprue. For his efforts in elimination of pellagra, Time Magazine named him as 1938 "Man of the Year" in comprehensive science. [1]
[4] [5] Niacin as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency. Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness. [6] Many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra. [4] [7]
The Casal collar or Casal necklace is a medical sign in which there is a redness and darkening of the skin around the neck, seen in people with pellagra. [2] It becomes prominent following exposure to sun, and can be itchy with a burning feeling and pain. [1] It can blister and weep, and turn into thick dark skin, with a coppery hue. [1]
Gaspar Roque Francisco Narciso Casal Julian (31 December 1681 – 10 August 1759) was a Spanish physician remembered for describing the Casal collar in pellagra. Casal was born in Girona Catalonia, Spain to Federico Casal y Dajón and Magdalena Julian.
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Sambon introduced the parasitic theory at the meeting of the British Medical Association in 1905, in which he stated that pellagra was an infectious disease something like kala-azar (caused by a protozoan Leishmania) in India. [15] He was assigned to investigate pellagra in Italy for three months in 1910.
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