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Anti-HER2 antibody. HER2-positive breast cancer, gastric cancer, pancreatic cancer (orphan) and gastro-oesophageal junction cancer. Cardiac dysfunction, infusion-related reactions, peripheral neuropathy and pulmonary toxicity (rare). 2.2 Tyrosine kinase inhibitor: Afatinib: PO: EGFR, HER2 and HER4 inhibitor. Non-small cell lung cancer.
Treatment of adults with unresectable or metastatic HER2- positive (IHC 3+) solid tumors who have received prior systemic treatment and have no satisfactory alternative treatment options [2] Vorasidenib: Treatment of people aged 12 years of age and older with Grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation ...
Over-expression is also known to occur in ovarian, [19] stomach, adenocarcinoma of the lung [20] and aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma, [21] [22] e.g. HER2 is over-expressed in approximately 7-34% of patients with gastric cancer [23] [24] and in 30% of salivary duct carcinomas.
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. [31] [28] [32] [33] It is specifically used for cancer that is HER2 receptor positive. [31] It may be used by itself or together with other chemotherapy medication. [31]
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. [144] [141] [145] [146] It is specifically used for cancer that is HER2 receptor positive. [144] It may be used by itself or together with other chemotherapy medication. [144]
Stomach cancer, also known as gastric cancer, is a malignant tumor of the stomach. It's a cancer that develops from the lining of the stomach . [ 10 ] Most cases of stomach cancers are gastric carcinomas , which can be divided into a number of subtypes, including gastric adenocarcinomas . [ 2 ]
Pertuzumab is administered as an intravenous infusion in combination with trastuzumab and docetaxel as a first line treatment for HER2-positive metastatic breast cancer. [4] [3] It is also used in the same combination as a neoadjuvant (given to reduce the size of a tumor, prior to surgery or radiation) for HER2-positive early breast cancer; as of 2016 this use had not been shown to increase ...
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
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