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NUT carcinoma (NC; formerly NUT midline carcinoma (NMC)) is a rare genetically defined, very aggressive squamous cell epithelial cancer that usually arises in the midline of the body and is characterized by a chromosomal rearrangement in the nuclear protein in testis gene (i.e. NUTM1 gene). [2]
NUT carcinoma is a rare, highly aggressive malignancy. Initially, it was regarded as occurring in the midline areas of the upper respiratory tract, upper digestive tract, and mediastinum (i.e. central compartment of the thoracic cavity) of young adults and to lesser extents children and infants. It was therefore termed NUT midline granuloma.
NUT carcinoma is a rare, aggressive cancer that thrives in the head, neck and lungs, according to Dana-Farber Cancer Institute. Being diagnosed with a little-known cancer felt overwhelming.
[5] [6] In 2010 the use of JQ1, a tert-butyl synthetic precursor of OTX-015, was published having activity in vitro in NUT midline carcinoma. [7] Since this time a number of molecules have been described that are capable of targeting BET bromodomains. [8]
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Salivary gland–like carcinoma of the lung; Sarcoma botryoides; Secretory carcinoma; Sertoli cell tumour; Sertoli–Leydig cell tumour; Sinonasal undifferentiated carcinoma; Somatostatinoma; Splenic lymphoma with villous lymphocytes; Squamous-cell carcinoma of the thyroid