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What is a GLP-1 medication? GLP-1 medications are drugs that mimic the effects of the GLP-1 hormone, helping regulate blood sugar and reduce appetite. They are primarily used for managing type 2 ...
The researchers who conducted the new review utilized data from hundreds of clinical studies, preclinical studies, controlled trials, and meta-analyses to learn more about how GLP-1 medications ...
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A new study compares the benefits and risks of taking GLP-1 medications for weight loss, including risks of dementia, addiction, heart disease, and gastrointestinal problems, among others.
A previous review of 28 randomized control trials showed that GLP-1s lowered the incidence of respiratory diseases. ... As the GLP-1 patients in Al-Aly’s study were all veterans, with full drug ...
The initial product GLP-1 (1–37) is susceptible to amidation and proteolytic cleavage, which gives rise to the two truncated and equipotent biologically active forms, GLP-1 (7–36) amide and GLP-1 (7–37). Active GLP-1 protein secondary structure includes two α-helices from amino acid position 13–20 and 24–35 separated by a linker region.
Native GLP-1 is a peptide hormone with a half-life of two minutes because it is rapidly cleared by the enzyme dipeptidyl peptidase-4. [29] As a result, different GLP-1 agonist drugs are modified in various ways to extend the half-life, resulting in drugs that can be dosed multiple times per day, daily, weekly, or less often. [29]
Because GLP-1 users tend to get this very critical piece of advice: "GLP-1s slow digestion, which can cause food to sit in your stomach longer and lead to nausea," Cardel said. "To avoid this, I ...